藥品參考
Daridorexant
Daridorexant is a medicine in the class central nervous system. It is used for insomnia.
- 藥物類別: Central Nervous System
- 用途: insomnia
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- ATC 代碼
- N05CJ03
- 常見劑型
- 錠劑
- 已知交互作用
- 173 (嚴重: 12 · 中度: 146 · 輕微: 15)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Presumed to act through antagonism of orexin receptors; blocking binding of orexin A and orexin B to OX1R and OX2R is thought to suppress wake drive.
成人常用劑量（仿單摘要）
Insomnia (sleep onset and/or maintenance): 25 mg to 50 mg orally once per night, within 30 minutes of going to bed, with at least 7 hours remaining before planned awakening.
懷孕與哺乳
- 懷孕
- Unknown No human pregnancy data. In rats and rabbits, doses up to 8-10 times human exposure caused no fetal toxicity or malformations. A US pregnancy registry exists. Prefer non-drug measures for insomnia in pregnancy; use only if clearly needed.
- 哺乳
- Safe Passes into milk in very low amounts (well under 1% of the mother's weight-adjusted dose). LactMed: not a reason to stop breastfeeding. US label: watch the infant for excessive sedation; also check feeding and weight gain.
已通報的副作用
- Headache
- Somnolence or fatigue
- Dizziness
- Nausea
- Nightmares or abnormal dreams (post-marketing)
- Hypersensitivity including angioedema, rash, urticaria (post-marketing)
禁忌症
- Narcolepsy.
- History of hypersensitivity to daridorexant or any component of the product; angioedema with pharyngeal involvement has been reported.
哪些人需要特別留意
- CNS depressant effects and daytime impairment, which may persist for several days; caution against next-day driving; risk increases with less than a full night of sleep remaining, higher doses, or other CNS depressants; falls risk especially in the elderly.
- Worsening of depression and suicidal ideation; use with caution in patients with depressive symptoms and monitor suicide risk.
- Sleep paralysis, hypnagogic/hypnopompic hallucinations and cataplexy-like symptoms may occur.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (173)
- Amobarbital + Daridorexant Major
- Apalutamide + Daridorexant Major
- Clarithromycin + Daridorexant Major
- Daridorexant + Enzalutamide Major
- Daridorexant + Fluvoxamine Major
- Daridorexant + Itraconazole Major
- Daridorexant + Ketoconazole Major
- Daridorexant + Mifepristone Major
- Daridorexant + Phenytoin Major
- Daridorexant + Posaconazole Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Daridorexant 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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常見問題
What is Daridorexant used for?
Daridorexant is a medicine in the class central nervous system. It is used for Insomnia.
What side effects have been reported with Daridorexant?
Headache, Somnolence or fatigue, Dizziness, Nausea, Nightmares or abnormal dreams (post-marketing), Hypersensitivity including angioedema, rash, urticaria (post-marketing).
Can Daridorexant be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human pregnancy data. In rats and rabbits, doses up to 8-10 times human exposure caused no fetal toxicity or malformations. A US pregnancy registry exists. Prefer non-drug measures for insomnia in pregnancy; use only if clearly needed. Breastfeeding: Safe. Passes into milk in very low amounts (well under 1% of the mother's weight-adjusted dose). LactMed: not a reason to stop breastfeeding. US label: watch the infant for excessive sedation; also check feeding and weight gain.
What does Daridorexant interact with?
MediHelp lists 173 known interactions for Daridorexant. Major: 12 · Moderate: 146 · Minor: 15. The most serious include Amobarbital, Apalutamide, Clarithromycin.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
