藥物交互作用
Daridorexant + Enzalutamide
嚴重程度: 嚴重
Daridorexant and Enzalutamide: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Enzalutamide strongly lowers daridorexant exposure, likely rendering it ineffective for insomnia.
用白話說明這項交互作用的意義
Daridorexant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
為什麼會發生
CYP3A4 induction by enzalutamide increases the metabolism of daridorexant.
處置方式
Avoid use with strong CYP3A inducers per labeling. Choose an alternative hypnotic not dependent on CYP3A4.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Enzalutamide 的其他交互作用
Daridorexant 的其他交互作用
常見問題
Can I take Daridorexant with Enzalutamide?
MediHelp rates the interaction as major. Daridorexant and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide strongly lowers daridorexant exposure, likely rendering it ineffective for insomnia.
How serious is the interaction between Daridorexant and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use with strong CYP3A inducers per labeling. Choose an alternative hypnotic not dependent on CYP3A4.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
