藥物交互作用
Clarithromycin + Daridorexant
嚴重程度: 嚴重
Clarithromycin and Daridorexant: major interaction.
最後更新 來源: UK SmPC
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摘要
Strong CYP3A4 inhibitors markedly increase daridorexant exposure, causing excessive sedation, next-day somnolence and impaired psychomotor performance. Labeling advises against combining daridorexant with strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Clarithromycin and Daridorexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Daridorexant belongs to Central Nervous System.
為什麼會發生
Clarithromycin is a strong CYP3A4 inhibitor and reduces the main clearance pathway of daridorexant.
處置方式
Avoid the combination and use a non-interacting antibiotic such as azithromycin. If a short course of clarithromycin is essential, withhold daridorexant during treatment.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Clarithromycin 的其他交互作用
Daridorexant 的其他交互作用
常見問題
Can I take Clarithromycin with Daridorexant?
MediHelp rates the interaction as major. Clarithromycin and Daridorexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors markedly increase daridorexant exposure, causing excessive sedation, next-day somnolence and impaired psychomotor performance. Labeling advises against combining daridorexant with strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Daridorexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-interacting antibiotic such as azithromycin. If a short course of clarithromycin is essential, withhold daridorexant during treatment.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
