藥物交互作用
Daridorexant + Fluvoxamine
嚴重程度: 嚴重
Daridorexant and Fluvoxamine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Fluvoxamine moderately inhibits CYP3A4, increasing daridorexant exposure and the risk of next-day somnolence and psychomotor impairment. Additive CNS depression may occur.
用白話說明這項交互作用的意義
Daridorexant and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
為什麼會發生
CYP3A4 inhibition reducing daridorexant clearance, plus additive CNS depressant effects.
處置方式
Limit daridorexant to a maximum of 25 mg nightly. Counsel patients about daytime drowsiness and driving impairment.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluvoxamine 的其他交互作用
Daridorexant 的其他交互作用
常見問題
Can I take Daridorexant with Fluvoxamine?
MediHelp rates the interaction as major. Daridorexant and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluvoxamine moderately inhibits CYP3A4, increasing daridorexant exposure and the risk of next-day somnolence and psychomotor impairment. Additive CNS depression may occur.
How serious is the interaction between Daridorexant and Fluvoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to a maximum of 25 mg nightly. Counsel patients about daytime drowsiness and driving impairment.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
