藥物交互作用

Apalutamide + Daridorexant

嚴重程度: 嚴重

Apalutamide and Daridorexant: major interaction.

最後更新 29 十月 2026 來源: US FDA label

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本頁的臨床內容僅提供英文版。

摘要

Apalutamide can substantially reduce daridorexant exposure, causing loss of insomnia efficacy. Daridorexant labeling advises avoiding strong CYP3A4 inducers.

用白話說明這項交互作用的意義

Apalutamide and Daridorexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apalutamide belongs to Endocrine; Daridorexant belongs to Central Nervous System.

證據等級: Moderate

為什麼會發生

Induction of CYP3A4 increases daridorexant clearance.

處置方式

Avoid the combination and use a non-CYP3A4-dependent hypnotic if sleep treatment is needed.

可向藥師詢問的問題

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Apalutamide 與 Daridorexant 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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參考資料

ERLEADA - FDA drug label (DailyMed) - section 7 Drug Interactions (class statement: substrates of CYP3A4; "Concomitant use with medications that are sensitive substrates of CYP3A4, CYP2C19, CYP2C9, UGT, P-gp, BCRP, or OATP1B1 may result in loss of activity of these m") — DailyMed (FDA label)

Apalutamide + Cabotegravir 禁忌併用
Apalutamide + Cobicistat 禁忌併用
Apalutamide + Doravirine 禁忌併用
Apalutamide + Elbasvir / grazoprevir 禁忌併用
Apalutamide + Ensitrelvir 禁忌併用
Apalutamide + Fostemsavir 禁忌併用

常見問題

Can I take Apalutamide with Daridorexant?

MediHelp rates the interaction as major. Apalutamide and Daridorexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide can substantially reduce daridorexant exposure, causing loss of insomnia efficacy. Daridorexant labeling advises avoiding strong CYP3A4 inducers.

How serious is the interaction between Apalutamide and Daridorexant?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-dependent hypnotic if sleep treatment is needed.

What other medicines interact with Apalutamide?

MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.

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摘要