藥物交互作用
Daridorexant + Ketoconazole
嚴重程度: 嚴重
Daridorexant and Ketoconazole: major interaction.
最後更新 來源: US FDA label
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摘要
Ketoconazole markedly raises daridorexant exposure, increasing the risk of excessive sedation, next-day somnolence and impaired driving. Labeling advises against combining daridorexant with strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Daridorexant and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daridorexant belongs to Central Nervous System; Ketoconazole belongs to Anti Fungals.
為什麼會發生
Strong CYP3A4 inhibition by ketoconazole decreases the clearance of daridorexant.
處置方式
Avoid the combination and choose a different hypnotic or antifungal. If unavoidable, use the lowest daridorexant dose and monitor for daytime sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Ketoconazole 的其他交互作用
Daridorexant 的其他交互作用
常見問題
Can I take Daridorexant with Ketoconazole?
MediHelp rates the interaction as major. Daridorexant and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole markedly raises daridorexant exposure, increasing the risk of excessive sedation, next-day somnolence and impaired driving. Labeling advises against combining daridorexant with strong CYP3A4 inhibitors.
How serious is the interaction between Daridorexant and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a different hypnotic or antifungal. If unavoidable, use the lowest daridorexant dose and monitor for daytime sedation.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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