藥品參考
Panobinostat
Panobinostat is a medicine in the class oncology. It is used for multiple myeloma.
- 藥物類別: Oncology
- 用途: multiple myeloma
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01XH03
- 已知交互作用
- 107 (禁忌併用: 12 · 嚴重: 80 · 中度: 13 · 輕微: 2)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Histone deacetylase (HDAC) inhibitor that inhibits HDAC enzymatic activity at nanomolar concentrations, increasing histone acetylation and causing cell cycle arrest and/or apoptosis of some transformed cells.
成人常用劑量（仿單摘要）
Relapsed/refractory multiple myeloma (with bortezomib and dexamethasone): 20 mg orally once a day on days 1, 3, 5, 8, 10 and 12 of a 21-day cycle; treat 8 cycles, then 8 more cycles if clinical benefit; up to 16 cycles (48 weeks)
懷孕與哺乳
- 懷孕
- Unsafe No clinical studies in pregnancy; animal studies show embryo-foetal toxicity and the potential foetal risk is high. Use only if benefit outweighs risk.
- 哺乳
- Unsafe Unknown if excreted in human milk; breast-feeding is contraindicated during treatment.
已通報的副作用
- Diarrhoea
- Fatigue
- Nausea
- Vomiting
- Thrombocytopenia
- Anaemia
禁忌症
- Hypersensitivity to the active substance or any excipient.
- Breast-feeding.
哪些人需要特別留意
- Severe thrombocytopenia, neutropenia and anaemia: perform a complete blood count before treatment and monitor frequently.
- Haemorrhage, including fatal GI and pulmonary haemorrhage; higher risk with coagulation disorders or anticoagulants.
- Serious and fatal infections; do not start in active infection.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (107)
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Moxifloxacin + Panobinostat Contraindicated
- Panobinostat + Pimozide Contraindicated
- Panobinostat + Quinidine Contraindicated
- Panobinostat + Sotalol Contraindicated
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Panobinostat 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Panobinostat used for?
Panobinostat is a medicine in the class oncology. It is used for Multiple myeloma.
What side effects have been reported with Panobinostat?
Diarrhoea, Fatigue, Nausea, Vomiting, Thrombocytopenia, Anaemia.
Can Panobinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No clinical studies in pregnancy; animal studies show embryo-foetal toxicity and the potential foetal risk is high. Use only if benefit outweighs risk. Breastfeeding: Unsafe. Unknown if excreted in human milk; breast-feeding is contraindicated during treatment.
What does Panobinostat interact with?
MediHelp lists 107 known interactions for Panobinostat. Contraindicated: 12 · Major: 80 · Moderate: 13 · Minor: 2. The most serious include Amiodarone, Anagrelide, Chloroquine.
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