藥物交互作用
Chloroquine + Panobinostat
嚴重程度: 禁忌併用
Chloroquine and Panobinostat: contraindicated interaction.
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摘要
Panobinostat significantly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs such as chloroquine. Combined use increases the risk of torsades de pointes and sudden cardiac death.
用白話說明這項交互作用的意義
Chloroquine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chloroquine belongs to Anti Parasitic; Panobinostat belongs to Oncology.
為什麼會發生
Additive prolongation of cardiac repolarization (QTc).
處置方式
Do not combine; use a non-QT-prolonging alternative to chloroquine during panobinostat therapy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Chloroquine 的其他交互作用
Panobinostat 的其他交互作用
常見問題
Can I take Chloroquine with Panobinostat?
MediHelp rates the interaction as contraindicated. Chloroquine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat significantly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs such as chloroquine. Combined use increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Chloroquine and Panobinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging alternative to chloroquine during panobinostat therapy.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
