藥品參考
Sargramostim
Sargramostim is a medicine in the class miscellaneous. It is used for acute lymphocytic leukemia.
- 藥物類別: Miscellaneous
- 用途: acute lymphocytic leukemia
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- L03AA09
- 常見劑型
- 注射劑
- 常見規格
- 250 mcg/ml
- 已知交互作用
- 3 (中度: 1 · 輕微: 2)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Sargramostim (GM-CSF) is a colony-stimulating factor that supports survival, clonal expansion and differentiation of hematopoietic progenitor cells, driving granulocyte-macrophage lineages (neutrophils, monocytes/macrophages, dendritic cells) and activating mature granulocytes and macrophages.
成人常用劑量（仿單摘要）
AML, neutrophil recovery after induction chemotherapy: 250 mcg/m2/day IV over 4 hours, starting about day 11 or 4 days after chemotherapy if day 10 marrow hypoplastic with <5% blasts; continue until ANC >1500 cells/mm3 for 3 consecutive days or maximum 42 days
懷孕與哺乳
- 懷孕
- Unknown Limited human data. In rabbits it increased miscarriage at about 1.3 times human exposure. If needed in pregnancy, reconstitute only with sterile water (no benzyl alcohol). Filgrastim has more pregnancy data.
- 哺乳
- Safe No data with injected use; GM-CSF is a normal milk component and is largely digested in the infant's gut. US label: do not breastfeed during treatment and for at least 2 weeks after (lower pup survival in rabbits). LactMed: unlikely to affect the infant.
已通報的副作用
- Fever
- Nausea
- Diarrhea
- Vomiting
- Mucous membrane disorder
- Alopecia
禁忌症
- History of serious allergic reactions, including anaphylaxis, to human GM-CSF such as sargramostim, yeast-derived products, or any component of the product
哪些人需要特別留意
- Serious hypersensitivity reactions including anaphylaxis: discontinue permanently for serious allergic reactions
- Infusion-related reactions (respiratory distress, hypoxia, flushing, hypotension, syncope, tachycardia), especially with pre-existing lung disease
- Do not give within 24 hours before or after chemotherapy or radiotherapy because of severe myelosuppression risk
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (3)
- Ifosfamide + Sargramostim Moderate
- Hydrocortisone + Sargramostim Minor
- Lithium + Sargramostim Minor
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Sargramostim 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
在網頁版免費試用 Pro+ 7 天，無需信用卡。
同類別的其他藥品
常見問題
What is Sargramostim used for?
Sargramostim is a medicine in the class miscellaneous. It is used for Acute lymphocytic leukemia, Hodgkin lymphoma, Non-hodgkin lymphoma, Radiation syndrome.
What side effects have been reported with Sargramostim?
Fever, Nausea, Diarrhea, Vomiting, Mucous membrane disorder, Alopecia.
Can Sargramostim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. In rabbits it increased miscarriage at about 1.3 times human exposure. If needed in pregnancy, reconstitute only with sterile water (no benzyl alcohol). Filgrastim has more pregnancy data. Breastfeeding: Safe. No data with injected use; GM-CSF is a normal milk component and is largely digested in the infant's gut. US label: do not breastfeed during treatment and for at least 2 weeks after (lower pup survival in rabbits). LactMed: unlikely to affect the infant.
What does Sargramostim interact with?
MediHelp lists 3 known interactions for Sargramostim. Moderate: 1 · Minor: 2. The most serious include Ifosfamide, Hydrocortisone, Lithium.
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