藥品參考
Avatrombopag
Avatrombopag is a medicine in the class miscellaneous. It is used for thrombocytopenia.
- 藥物類別: Miscellaneous
- 用途: thrombocytopenia
最後更新 來源: EMA SmPC, US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- 常見劑型
- 錠劑
- 常見規格
- 20 mg, 10 mg
- 已知交互作用
- 12 (中度: 11 · 輕微: 1)
- 商品名
- 4
- 國家與市場
- 3
用途
作用方式
Orally bioavailable small molecule TPO receptor agonist that stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, increasing platelet production. It does not compete with TPO for receptor binding and has an additive effect with TPO.
成人常用劑量（仿單摘要）
Thrombocytopenia in chronic liver disease before a procedure (tablets): platelet count less than 40×10 9 /L: 60 mg (3 tablets) orally once daily for 5 days, starting 10 to 13 days before the procedure
懷孕與哺乳
- 懷孕
- Unknown Animal studies showed miscarriage in rabbits and pup deaths in rats at high exposures; human data are insufficient. May cause fetal harm. Use only if benefit outweighs risk and inform the patient of the potential risk.
- 哺乳
- Unsafe No human milk data; present in rat milk. US label: do not breastfeed during treatment and for at least 2 weeks after the last dose; after a short pre-procedure course, pump and discard milk for that period.
已通報的副作用
- Pyrexia
- Abdominal pain
- Nausea
- Headache
- Fatigue
- Contusion
禁忌症
- None.
哪些人需要特別留意
- Thrombotic/thromboembolic complications: TPO receptor agonists are associated with thrombotic and thromboembolic events; monitor platelet counts and for signs of thromboembolism, and treat promptly.
- Consider increased thrombotic risk in patients with known risk factors, including genetic prothrombotic conditions and acquired factors such as antiphospholipid syndrome.
- Do not use to normalize platelet counts.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (12)
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Fluconazole Moderate
- Avatrombopag + Ketoconazole Moderate
- Avatrombopag + Mifepristone Moderate
- Avatrombopag + Phenytoin Moderate
- Avatrombopag + Secobarbital Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Avatrombopag 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 14 天，無需信用卡。
同類別的其他藥品
常見問題
What is Avatrombopag used for?
Avatrombopag is a medicine in the class miscellaneous. It is used for Thrombocytopenia, Thrombocytopenic purpura.
What side effects have been reported with Avatrombopag?
Pyrexia, Abdominal pain, Nausea, Headache, Fatigue, Contusion.
Can Avatrombopag be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Animal studies showed miscarriage in rabbits and pup deaths in rats at high exposures; human data are insufficient. May cause fetal harm. Use only if benefit outweighs risk and inform the patient of the potential risk. Breastfeeding: Unsafe. No human milk data; present in rat milk. US label: do not breastfeed during treatment and for at least 2 weeks after the last dose; after a short pre-procedure course, pump and discard milk for that period.
What does Avatrombopag interact with?
MediHelp lists 12 known interactions for Avatrombopag. Moderate: 11 · Minor: 1. The most serious include Amiodarone, Amobarbital, Bosentan.
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