藥物交互作用
Rifampicin + Thalidomide
嚴重程度: 嚴重
Rifampicin and Thalidomide: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Rifampicin is a strong enzyme inducer that substantially lowers hormonal contraceptive levels, risking contraceptive failure. With thalidomide, a pregnancy would carry a risk of severe birth defects.
用白話說明這項交互作用的意義
Rifampicin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Thalidomide belongs to Miscellaneous.
為什麼會發生
Induction of CYP3A4 and other enzymes by rifampicin increases contraceptive hormone metabolism.
處置方式
Do not depend on hormonal contraceptives; use a non-hormonal highly effective method such as a copper IUD plus a barrier method during and for several weeks after rifampicin.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Thalidomide 的其他交互作用
Rifampicin 的其他交互作用
常見問題
Can I take Rifampicin with Thalidomide?
MediHelp rates the interaction as major. Rifampicin and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin is a strong enzyme inducer that substantially lowers hormonal contraceptive levels, risking contraceptive failure. With thalidomide, a pregnancy would carry a risk of severe birth defects.
How serious is the interaction between Rifampicin and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not depend on hormonal contraceptives; use a non-hormonal highly effective method such as a copper IUD plus a barrier method during and for several weeks after rifampicin.
What other medicines interact with Thalidomide?
MediHelp also lists interactions of Thalidomide with, for example, Bortezomib, Carbamazepine, Griseofulvin. The full list is on the Thalidomide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
