藥物交互作用
Acetylsalicylic acid + Caplacizumab
嚴重程度: 嚴重
Acetylsalicylic acid and Caplacizumab: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion, and aspirin inhibits platelet aggregation, so combined use increases the risk of bleeding. Aspirin is sometimes used alongside caplacizumab in aTTP, but bleeding such as epistaxis and gingival bleeding is more likely.
用白話說明這項交互作用的意義
Acetylsalicylic acid and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Caplacizumab belongs to Cardiovascular.
為什麼會發生
Additive impairment of platelet function and primary hemostasis via different pathways.
處置方式
Monitor closely for bleeding and hold caplacizumab before any invasive procedure. Use aspirin only when clearly indicated and review the need if bleeding occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Acetylsalicylic acid 的其他交互作用
Caplacizumab 的其他交互作用
常見問題
Can I take Acetylsalicylic acid with Caplacizumab?
MediHelp rates the interaction as major. Acetylsalicylic acid and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion, and aspirin inhibits platelet aggregation, so combined use increases the risk of bleeding. Aspirin is sometimes used alongside caplacizumab in aTTP, but bleeding such as epistaxis and gingival bleeding is more likely.
How serious is the interaction between Acetylsalicylic acid and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and hold caplacizumab before any invasive procedure. Use aspirin only when clearly indicated and review the need if bleeding occurs.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
