藥物交互作用
Argatroban + Caplacizumab
嚴重程度: 嚴重
Argatroban and Caplacizumab: major interaction.
最後更新
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摘要
Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and argatroban inhibits thrombin, so the combination increases the risk of bleeding.
用白話說明這項交互作用的意義
Argatroban and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic effect on hemostasis through antiplatelet adhesion and anticoagulant actions.
處置方式
Avoid the combination unless benefit outweighs risk. If it is used, monitor aPTT and closely watch for bleeding, and consider holding caplacizumab if serious bleeding occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Argatroban 的其他交互作用
Caplacizumab 的其他交互作用
常見問題
Can I take Argatroban with Caplacizumab?
MediHelp rates the interaction as major. Argatroban and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and argatroban inhibits thrombin, so the combination increases the risk of bleeding.
How serious is the interaction between Argatroban and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless benefit outweighs risk. If it is used, monitor aPTT and closely watch for bleeding, and consider holding caplacizumab if serious bleeding occurs.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
