藥物交互作用
Caplacizumab + Clopidogrel
嚴重程度: 嚴重
Caplacizumab and Clopidogrel: major interaction.
最後更新
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摘要
Caplacizumab inhibits von Willebrand factor-platelet interaction, and adding clopidogrel increases the risk of bleeding. Mucosal and other bleeding events may be more frequent.
用白話說明這項交互作用的意義
Caplacizumab and Clopidogrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caplacizumab belongs to Cardiovascular; Clopidogrel belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic effect on primary hemostasis from anti-vWF activity and P2Y12 inhibition.
處置方式
Avoid combining unless clearly necessary; if used, monitor for bleeding and consider holding caplacizumab if bleeding occurs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clopidogrel 的其他交互作用
Caplacizumab 的其他交互作用
常見問題
Can I take Caplacizumab with Clopidogrel?
MediHelp rates the interaction as major. Caplacizumab and Clopidogrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab inhibits von Willebrand factor-platelet interaction, and adding clopidogrel increases the risk of bleeding. Mucosal and other bleeding events may be more frequent.
How serious is the interaction between Caplacizumab and Clopidogrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly necessary; if used, monitor for bleeding and consider holding caplacizumab if bleeding occurs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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