藥物交互作用
Alteplase + Caplacizumab
嚴重程度: 嚴重
Alteplase and Caplacizumab: major interaction.
最後更新
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摘要
Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and thrombolysis with alteplase adds fibrinolytic activity. Together they substantially raise the risk of severe bleeding.
用白話說明這項交互作用的意義
Alteplase and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alteplase belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic effect of impaired platelet adhesion and plasmin-mediated fibrin breakdown.
處置方式
Avoid concurrent use unless thrombolysis is clearly essential; if so, withhold caplacizumab and monitor closely for bleeding with ready access to supportive care.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Alteplase 的其他交互作用
Caplacizumab 的其他交互作用
常見問題
Can I take Alteplase with Caplacizumab?
MediHelp rates the interaction as major. Alteplase and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and thrombolysis with alteplase adds fibrinolytic activity. Together they substantially raise the risk of severe bleeding.
How serious is the interaction between Alteplase and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless thrombolysis is clearly essential; if so, withhold caplacizumab and monitor closely for bleeding with ready access to supportive care.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
