藥物交互作用
Acetylsalicylic acid + Lesinurad
嚴重程度: 中度
Acetylsalicylic acid and Lesinurad: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
用白話說明這項交互作用的意義
Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Lesinurad belongs to Genitourinary.
為什麼會發生
Salicylates interfere with renal urate handling at the tubular level, and this may counteract the uricosuric effect, though the exact mechanism is not firmly established.
處置方式
Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Acetylsalicylic acid 的其他交互作用
Lesinurad 的其他交互作用
常見問題
Can I take Acetylsalicylic acid with Lesinurad?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
How serious is the interaction between Acetylsalicylic acid and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
