藥物交互作用
Lesinurad + Norethisterone
嚴重程度: 嚴重
Lesinurad and Norethisterone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Lesinurad can lower systemic exposure to norethisterone, which may reduce contraceptive reliability and raise the risk of unintended pregnancy. Breakthrough bleeding or loss of cycle control may also occur.
用白話說明這項交互作用的意義
Lesinurad and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lesinurad belongs to Genitourinary; Norethisterone belongs to Endocrine.
為什麼會發生
Lesinurad is a weak CYP3A inducer that may increase the metabolism of norethisterone.
處置方式
Do not rely on norethisterone alone for contraception; add a nonhormonal barrier method during lesinurad therapy and for a period after stopping. Consider an alternative urate-lowering agent if effective hormonal contraception is essential.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Norethisterone 的其他交互作用
Lesinurad 的其他交互作用
常見問題
Can I take Lesinurad with Norethisterone?
MediHelp rates the interaction as major. Lesinurad and Norethisterone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lesinurad can lower systemic exposure to norethisterone, which may reduce contraceptive reliability and raise the risk of unintended pregnancy. Breakthrough bleeding or loss of cycle control may also occur.
How serious is the interaction between Lesinurad and Norethisterone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on norethisterone alone for contraception; add a nonhormonal barrier method during lesinurad therapy and for a period after stopping. Consider an alternative urate-lowering agent if effective hormonal contraception is essential.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
