藥物交互作用
Amiodarone + Lesinurad
嚴重程度: 中度
Amiodarone and Lesinurad: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Amiodarone inhibits CYP2C9 and may raise lesinurad exposure, potentially increasing adverse effects such as renal toxicity. The clinical impact is uncertain but is relevant given lesinurad's renal safety profile.
用白話說明這項交互作用的意義
Amiodarone and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Lesinurad belongs to Genitourinary.
為什麼會發生
Amiodarone inhibits CYP2C9, the main enzyme metabolizing lesinurad.
處置方式
Monitor serum creatinine and for renal adverse effects when lesinurad is combined with amiodarone. Consider alternative urate-lowering therapy if renal function declines.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Lesinurad 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Lesinurad?
MediHelp rates the interaction as moderate. Amiodarone and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP2C9 and may raise lesinurad exposure, potentially increasing adverse effects such as renal toxicity. The clinical impact is uncertain but is relevant given lesinurad's renal safety profile.
How serious is the interaction between Amiodarone and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and for renal adverse effects when lesinurad is combined with amiodarone. Consider alternative urate-lowering therapy if renal function declines.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Apalutamide. The full list is on the Lesinurad page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
