藥物交互作用
Desogestrel-ethinyl estradiol + Lesinurad
嚴重程度: 中度
Desogestrel-ethinyl estradiol and Lesinurad: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Lesinurad can reduce exposure to ethinyl estradiol and progestins, so hormonal contraceptives may be less effective. Lesinurad has been discontinued from the market, so this is now of limited practical relevance.
用白話說明這項交互作用的意義
Desogestrel-ethinyl estradiol and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Lesinurad belongs to Genitourinary.
為什麼會發生
Lesinurad is a weak CYP3A inducer that may lower contraceptive steroid concentrations.
處置方式
Recommend an additional non-hormonal contraceptive method if the combination is encountered. Do not rely on hormonal contraception alone.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Desogestrel-ethinyl estradiol 的其他交互作用
Lesinurad 的其他交互作用
常見問題
Can I take Desogestrel-ethinyl estradiol with Lesinurad?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad can reduce exposure to ethinyl estradiol and progestins, so hormonal contraceptives may be less effective. Lesinurad has been discontinued from the market, so this is now of limited practical relevance.
How serious is the interaction between Desogestrel-ethinyl estradiol and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional non-hormonal contraceptive method if the combination is encountered. Do not rely on hormonal contraception alone.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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