藥品參考
Lesinurad
Lesinurad is a medicine in the class genitourinary.
- 藥物類別: Genitourinary
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Genitourinary
- 已知交互作用
- 58 (嚴重: 1 · 中度: 23 · 輕微: 34)
- 商品名
- 1
作用方式
Selective uric acid reabsorption inhibitor (SURI); it acts by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. It also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia
成人常用劑量（仿單摘要）
Hyperuricemia: 200 mg PO qDay in combination with a xanthine oxidase inhibitor (ie, allopurinol or febuxostat)
懷孕與哺乳
- 懷孕
- Unknown Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait.
- 哺乳
- Unknown Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
已通報的副作用
- Headache
- Influenza
- Renal failure
- GERD
- Increased creatinine
禁忌症
- Severe renal impairment (estimated CrCl <30 mL/min), end-stage renal disease, kidney transplant recipients, or patients on dialysis
- Tumor lysis syndrome or Lesch-Nyhan syndrome
哪些人需要特別留意
- Contraindicated in Tumor lysis syndrome or Lesch-Nyhan syndrome.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (58)
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
- Ethinyl estradiol-drospirenone + Lesinurad Moderate
- Ethinyl estradiol-levonorgestrel + Lesinurad Moderate
- Ethinylestradiol + Lesinurad Moderate
- Etonogestrel + Lesinurad Moderate
同類別的其他藥品
常見問題
What is Lesinurad used for?
Lesinurad is a medicine in the class genitourinary.
What side effects have been reported with Lesinurad?
Headache, Influenza, Renal failure, GERD, Increased creatinine.
Can Lesinurad be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait. Breastfeeding: Unknown. Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
What does Lesinurad interact with?
MediHelp lists 58 known interactions for Lesinurad. Major: 1 · Moderate: 23 · Minor: 34. The most serious include Norethisterone, Acetylsalicylic acid, Amiodarone.
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