藥物交互作用
Aclidinium + Glycopyrronium
嚴重程度: 中度
Aclidinium and Glycopyrronium: moderate interaction.
最後更新
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摘要
Both drugs are antimuscarinics, so combining them gives additive anticholinergic effects such as dry mouth, urinary retention, constipation and raised intraocular pressure. Duplicate therapy provides little added benefit.
用白話說明這項交互作用的意義
Aclidinium and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive muscarinic receptor antagonism.
處置方式
Avoid concurrent use of two antimuscarinic bronchodilators or anticholinergics; if combined, monitor for urinary retention, glaucoma symptoms and constipation.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Glycopyrronium 的其他交互作用
常見問題
Can I take Aclidinium with Glycopyrronium?
MediHelp rates the interaction as moderate. Aclidinium and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antimuscarinics, so combining them gives additive anticholinergic effects such as dry mouth, urinary retention, constipation and raised intraocular pressure. Duplicate therapy provides little added benefit.
How serious is the interaction between Aclidinium and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antimuscarinic bronchodilators or anticholinergics; if combined, monitor for urinary retention, glaucoma symptoms and constipation.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Amantadine. The full list is on the Glycopyrronium page.
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