藥物交互作用
Clozapine + Glycopyrronium
嚴重程度: 嚴重
Clozapine and Glycopyrronium: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Clozapine has marked anticholinergic properties that add to those of glycopyrronium. This raises the risk of constipation, which with clozapine can progress to serious bowel obstruction or ileus, as well as urinary retention and tachycardia.
用白話說明這項交互作用的意義
Clozapine and Glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
為什麼會發生
Additive antimuscarinic effects, with cumulative reduction of gastrointestinal motility.
處置方式
Avoid the combination where possible; if used, monitor bowel function closely, use laxatives proactively, and stop glycopyrronium if constipation or retention develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Glycopyrronium 的其他交互作用
Clozapine 的其他交互作用
常見問題
Can I take Clozapine with Glycopyrronium?
MediHelp rates the interaction as major. Clozapine and Glycopyrronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine has marked anticholinergic properties that add to those of glycopyrronium. This raises the risk of constipation, which with clozapine can progress to serious bowel obstruction or ileus, as well as urinary retention and tachycardia.
How serious is the interaction between Clozapine and Glycopyrronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor bowel function closely, use laxatives proactively, and stop glycopyrronium if constipation or retention develops.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Abobotulinumtoxina, Aclidinium, Amantadine. The full list is on the Glycopyrronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
