藥物交互作用
Amitriptyline + Glycopyrronium
嚴重程度: 中度
Amitriptyline and Glycopyrronium: moderate interaction.
最後更新
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摘要
Amitriptyline has substantial anticholinergic activity that adds to glycopyrronium. This can cause marked dry mouth, constipation, urinary retention, tachycardia and cognitive impairment.
用白話說明這項交互作用的意義
Amitriptyline and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
為什麼會發生
Additive antimuscarinic effects at cholinergic receptors.
處置方式
Monitor for anticholinergic toxicity, especially in older adults or those with glaucoma or urinary obstruction, and consider an alternative antidepressant or lower doses.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Glycopyrronium 的其他交互作用
Amitriptyline 的其他交互作用
常見問題
Can I take Amitriptyline with Glycopyrronium?
MediHelp rates the interaction as moderate. Amitriptyline and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has substantial anticholinergic activity that adds to glycopyrronium. This can cause marked dry mouth, constipation, urinary retention, tachycardia and cognitive impairment.
How serious is the interaction between Amitriptyline and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older adults or those with glaucoma or urinary obstruction, and consider an alternative antidepressant or lower doses.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
