藥物交互作用
Ado-trastuzumab + Rozanolixizumab
嚴重程度: 中度
Ado-trastuzumab and Rozanolixizumab: moderate interaction.
最後更新
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摘要
Rozanolixizumab blocks the neonatal Fc receptor, which lowers circulating IgG levels. Ado-trastuzumab emtansine is an IgG1 antibody conjugate, so its exposure and efficacy could theoretically be reduced.
用白話說明這項交互作用的意義
Ado-trastuzumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ado-trastuzumab belongs to Oncology; Rozanolixizumab belongs to Miscellaneous.
為什麼會發生
FcRn blockade increases catabolism of IgG-based therapeutics such as trastuzumab emtansine.
處置方式
Monitor for reduced response to trastuzumab emtansine. Time rozanolixizumab cycles away from treatment where possible, or consider alternatives.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ado-trastuzumab 的其他交互作用
Rozanolixizumab 的其他交互作用
常見問題
Can I take Ado-trastuzumab with Rozanolixizumab?
MediHelp rates the interaction as moderate. Ado-trastuzumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor, which lowers circulating IgG levels. Ado-trastuzumab emtansine is an IgG1 antibody conjugate, so its exposure and efficacy could theoretically be reduced.
How serious is the interaction between Ado-trastuzumab and Rozanolixizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to trastuzumab emtansine. Time rozanolixizumab cycles away from treatment where possible, or consider alternatives.
What other medicines interact with Ado-trastuzumab?
MediHelp also lists interactions of Ado-trastuzumab with, for example, Atazanavir, Baricitinib, Ceritinib. The full list is on the Ado-trastuzumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
