藥物交互作用
Rozanolixizumab + Upadacitinib
嚴重程度: 嚴重
Rozanolixizumab and Upadacitinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Upadacitinib is a JAK inhibitor that suppresses immune signaling, while rozanolixizumab lowers circulating IgG by blocking the neonatal Fc receptor. Used together, the reduced IgG and impaired cellular immunity may raise the risk of serious infections.
用白話說明這項交互作用的意義
Rozanolixizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rozanolixizumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
為什麼會發生
Additive immunosuppression through JAK inhibition and FcRn-mediated IgG reduction.
處置方式
Avoid combining where possible; if both are necessary, screen for active infection beforehand and monitor closely for signs of infection. Interrupt therapy if a serious infection develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Upadacitinib 的其他交互作用
Rozanolixizumab 的其他交互作用
常見問題
Can I take Rozanolixizumab with Upadacitinib?
MediHelp rates the interaction as major. Rozanolixizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Upadacitinib is a JAK inhibitor that suppresses immune signaling, while rozanolixizumab lowers circulating IgG by blocking the neonatal Fc receptor. Used together, the reduced IgG and impaired cellular immunity may raise the risk of serious infections.
How serious is the interaction between Rozanolixizumab and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are necessary, screen for active infection beforehand and monitor closely for signs of infection. Interrupt therapy if a serious infection develops.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
