藥物交互作用
Alosetron + Eluxadoline
嚴重程度: 嚴重
Alosetron and Eluxadoline: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs slow bowel transit, and combining them raises the risk of severe constipation and complications such as ileus or ischemic colitis.
用白話說明這項交互作用的意義
Alosetron and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alosetron belongs to Gastrointestinal Tract; Eluxadoline belongs to Gastrointestinal Tract.
為什麼會發生
Additive pharmacodynamic reduction of gastrointestinal motility (opioid receptor activity with 5-HT3 antagonism).
處置方式
Avoid concomitant use; stop therapy and seek assessment if constipation or abdominal pain develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Eluxadoline 的其他交互作用
Alosetron 的其他交互作用
常見問題
Can I take Alosetron with Eluxadoline?
MediHelp rates the interaction as major. Alosetron and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow bowel transit, and combining them raises the risk of severe constipation and complications such as ileus or ischemic colitis.
How serious is the interaction between Alosetron and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; stop therapy and seek assessment if constipation or abdominal pain develops.
What other medicines interact with Eluxadoline?
MediHelp also lists interactions of Eluxadoline with, for example, Atropine, Buprenorphine, Cyclosporin. The full list is on the Eluxadoline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
