藥物交互作用
Atropine + Eluxadoline
嚴重程度: 嚴重
Atropine and Eluxadoline: major interaction.
最後更新
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摘要
Eluxadoline slows gut transit and can cause constipation and pancreatitis-related events, and atropine adds antimuscarinic suppression of gut motility. Together they raise the risk of severe constipation, ileus and related complications.
用白話說明這項交互作用的意義
Atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atropine belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.
為什麼會發生
Additive inhibition of gastrointestinal motility through opioid receptor agonism (eluxadoline) and muscarinic blockade (atropine).
處置方式
Avoid routine coadministration. If an anticholinergic is needed, monitor for constipation and abdominal distension and stop eluxadoline if severe constipation develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atropine 的其他交互作用
Eluxadoline 的其他交互作用
常見問題
Can I take Atropine with Eluxadoline?
MediHelp rates the interaction as major. Atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline slows gut transit and can cause constipation and pancreatitis-related events, and atropine adds antimuscarinic suppression of gut motility. Together they raise the risk of severe constipation, ileus and related complications.
How serious is the interaction between Atropine and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine coadministration. If an anticholinergic is needed, monitor for constipation and abdominal distension and stop eluxadoline if severe constipation develops.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Henbane, Pramlintide, Abobotulinumtoxina. The full list is on the Atropine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
