藥物交互作用
Eluxadoline + Hydromorphone
嚴重程度: 嚴重
Eluxadoline and Hydromorphone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
用白話說明這項交互作用的意義
Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Hydromorphone belongs to Musculoskeletal.
為什麼會發生
Additive inhibition of gastrointestinal motility via opioid receptor activity.
處置方式
Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Hydromorphone 的其他交互作用
Eluxadoline 的其他交互作用
常見問題
Can I take Eluxadoline with Hydromorphone?
MediHelp rates the interaction as major. Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
How serious is the interaction between Eluxadoline and Hydromorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
