藥物交互作用
Cyclosporin + Eluxadoline
嚴重程度: 嚴重
Cyclosporin and Eluxadoline: major interaction.
最後更新
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摘要
Cyclosporine inhibits OATP1B1 and can markedly increase eluxadoline exposure. This raises the risk of eluxadoline adverse effects such as constipation, pancreatitis, nausea and CNS effects.
用白話說明這項交互作用的意義
Cyclosporin and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.
為什麼會發生
Cyclosporine inhibits hepatic OATP1B1 uptake of eluxadoline, increasing systemic concentrations.
處置方式
Reduce eluxadoline to 75 mg twice daily if coadministration is needed. Monitor for pancreatitis symptoms, constipation and sedation, or choose an alternative agent.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cyclosporin 的其他交互作用
Eluxadoline 的其他交互作用
常見問題
Can I take Cyclosporin with Eluxadoline?
MediHelp rates the interaction as major. Cyclosporin and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits OATP1B1 and can markedly increase eluxadoline exposure. This raises the risk of eluxadoline adverse effects such as constipation, pancreatitis, nausea and CNS effects.
How serious is the interaction between Cyclosporin and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily if coadministration is needed. Monitor for pancreatitis symptoms, constipation and sedation, or choose an alternative agent.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
