藥物交互作用
Amiodarone + Loperamide
嚴重程度: 嚴重
Amiodarone and Loperamide: major interaction.
最後更新
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摘要
Amiodarone inhibits P-glycoprotein and may raise systemic loperamide exposure. Both drugs also prolong QT, so the arrhythmia risk is additive.
用白話說明這項交互作用的意義
Amiodarone and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Loperamide belongs to Gastrointestinal Tract.
為什麼會發生
P-gp inhibition increases loperamide absorption and central exposure, plus additive QT prolongation.
處置方式
Avoid doses of loperamide above labeled limits and consider alternatives for diarrhea. Monitor ECG and electrolytes if combined.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Loperamide 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Loperamide?
MediHelp rates the interaction as major. Amiodarone and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits P-glycoprotein and may raise systemic loperamide exposure. Both drugs also prolong QT, so the arrhythmia risk is additive.
How serious is the interaction between Amiodarone and Loperamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid doses of loperamide above labeled limits and consider alternatives for diarrhea. Monitor ECG and electrolytes if combined.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amisulpride, Anagrelide, Artemether / lumefantrine. The full list is on the Loperamide page.
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