藥物交互作用
Amisulpride + Loperamide
嚴重程度: 嚴重
Amisulpride and Loperamide: major interaction.
最後更新
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摘要
Both drugs can prolong the QT interval, and loperamide does so mainly at supratherapeutic doses. Together they increase the risk of torsades de pointes.
用白話說明這項交互作用的意義
Amisulpride and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Loperamide belongs to Gastrointestinal Tract.
為什麼會發生
Additive QT prolongation via cardiac potassium channel blockade.
處置方式
Avoid the combination if possible and keep loperamide at labeled doses. Obtain a baseline ECG and correct potassium and magnesium if coadministered.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Loperamide 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amisulpride with Loperamide?
MediHelp rates the interaction as major. Amisulpride and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and loperamide does so mainly at supratherapeutic doses. Together they increase the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Loperamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and keep loperamide at labeled doses. Obtain a baseline ECG and correct potassium and magnesium if coadministered.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Anagrelide, Artemether / lumefantrine. The full list is on the Loperamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
