藥物交互作用
Amitriptyline + Atropine
嚴重程度: 中度
Amitriptyline and Atropine: moderate interaction.
最後更新
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摘要
Both drugs have antimuscarinic activity, so combined use can produce additive effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients and those with glaucoma or prostatic hyperplasia are at particular risk.
用白話說明這項交互作用的意義
Amitriptyline and Atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Atropine belongs to Miscellaneous.
為什麼會發生
Additive blockade of muscarinic acetylcholine receptors.
處置方式
Monitor for anticholinergic toxicity such as urinary retention, ileus, confusion and tachycardia. Use the lowest effective doses or choose a less anticholinergic alternative in high-risk patients.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amitriptyline 的其他交互作用
Atropine 的其他交互作用
常見問題
Can I take Amitriptyline with Atropine?
MediHelp rates the interaction as moderate. Amitriptyline and Atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use can produce additive effects such as dry mouth, constipation, urinary retention, blurred vision and tachycardia. Older patients and those with glaucoma or prostatic hyperplasia are at particular risk.
How serious is the interaction between Amitriptyline and Atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, ileus, confusion and tachycardia. Use the lowest effective doses or choose a less anticholinergic alternative in high-risk patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
