藥物交互作用
Amitriptyline + Budesonide-formoterol
嚴重程度: 嚴重
Amitriptyline and Budesonide-formoterol: major interaction.
最後更新
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摘要
Formoterol can prolong the QT interval and raise heart rate, and amitriptyline has its own QT-prolonging and proarrhythmic effects. Tricyclics can also potentiate the cardiovascular effects of beta-agonists, so the combination may raise the risk of tachyarrhythmia and palpitations.
用白話說明這項交互作用的意義
Amitriptyline and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Budesonide-formoterol belongs to Respiratory.
為什麼會發生
Additive QT prolongation and adrenergic cardiovascular stimulation, with tricyclic potentiation of sympathomimetic effects.
處置方式
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and consider alternatives in patients with cardiac disease or other QT risk factors.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Budesonide-formoterol 的其他交互作用
Amitriptyline 的其他交互作用
常見問題
Can I take Amitriptyline with Budesonide-formoterol?
MediHelp rates the interaction as major. Amitriptyline and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Formoterol can prolong the QT interval and raise heart rate, and amitriptyline has its own QT-prolonging and proarrhythmic effects. Tricyclics can also potentiate the cardiovascular effects of beta-agonists, so the combination may raise the risk of tachyarrhythmia and palpitations.
How serious is the interaction between Amitriptyline and Budesonide-formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and consider alternatives in patients with cardiac disease or other QT risk factors.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
