藥物交互作用
Amitriptyline + Macimorelin
嚴重程度: 嚴重
Amitriptyline and Macimorelin: major interaction.
最後更新
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摘要
Macimorelin modestly prolongs the QT interval and amitriptyline has additional QT-prolonging potential, which could increase the risk of torsades de pointes during the diagnostic test. Macimorelin is given as a single test dose, so exposure is short.
用白話說明這項交互作用的意義
Amitriptyline and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Macimorelin belongs to Endocrine.
為什麼會發生
Additive QT interval prolongation.
處置方式
Avoid the combination. Where feasible, withhold amitriptyline for an adequate washout before the test, or use another growth hormone stimulation test.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amitriptyline 的其他交互作用
Macimorelin 的其他交互作用
常見問題
Can I take Amitriptyline with Macimorelin?
MediHelp rates the interaction as major. Amitriptyline and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin modestly prolongs the QT interval and amitriptyline has additional QT-prolonging potential, which could increase the risk of torsades de pointes during the diagnostic test. Macimorelin is given as a single test dose, so exposure is short.
How serious is the interaction between Amitriptyline and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Where feasible, withhold amitriptyline for an adequate washout before the test, or use another growth hormone stimulation test.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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