藥物交互作用
Amobarbital + Eltrombopag
嚴重程度: 中度
Amobarbital and Eltrombopag: moderate interaction.
最後更新
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摘要
Amobarbital may reduce eltrombopag exposure through enzyme induction, potentially weakening the platelet response. The effect is predicted rather than well characterized for this barbiturate.
用白話說明這項交互作用的意義
Amobarbital and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Eltrombopag belongs to Miscellaneous.
為什麼會發生
Barbiturate induction of hepatic enzymes such as CYP1A2 and CYP2C9 may increase eltrombopag clearance.
處置方式
Monitor platelet counts regularly after starting or stopping amobarbital and adjust the eltrombopag dose to maintain the target count.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amobarbital 的其他交互作用
Eltrombopag 的其他交互作用
常見問題
Can I take Amobarbital with Eltrombopag?
MediHelp rates the interaction as moderate. Amobarbital and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce eltrombopag exposure through enzyme induction, potentially weakening the platelet response. The effect is predicted rather than well characterized for this barbiturate.
How serious is the interaction between Amobarbital and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts regularly after starting or stopping amobarbital and adjust the eltrombopag dose to maintain the target count.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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