藥物交互作用
Atazanavir + Eltrombopag
嚴重程度: 中度
Atazanavir and Eltrombopag: moderate interaction.
最後更新
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摘要
Atazanavir inhibits UGT1A1, and eltrombopag is partly cleared by UGT1A1 and UGT1A3. Eltrombopag exposure may rise, and both drugs can raise bilirubin and liver enzymes.
用白話說明這項交互作用的意義
Atazanavir and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Eltrombopag belongs to Miscellaneous.
為什麼會發生
Atazanavir inhibits UGT1A1 and possibly CYP-mediated clearance, which may reduce eltrombopag elimination.
處置方式
Monitor liver function tests and bilirubin and review platelet response. Adjust the eltrombopag dose if hepatic abnormalities or excessive platelet counts occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Eltrombopag 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Eltrombopag?
MediHelp rates the interaction as moderate. Atazanavir and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits UGT1A1, and eltrombopag is partly cleared by UGT1A1 and UGT1A3. Eltrombopag exposure may rise, and both drugs can raise bilirubin and liver enzymes.
How serious is the interaction between Atazanavir and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and bilirubin and review platelet response. Adjust the eltrombopag dose if hepatic abnormalities or excessive platelet counts occur.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
