藥物交互作用
Berotralstat + Eltrombopag
嚴重程度: 中度
Berotralstat and Eltrombopag: moderate interaction.
最後更新
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摘要
Berotralstat is a BCRP substrate, and eltrombopag inhibits BCRP. Berotralstat exposure may increase, with more gastrointestinal and QT-related adverse effects.
用白話說明這項交互作用的意義
Berotralstat and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Eltrombopag belongs to Miscellaneous.
為什麼會發生
Eltrombopag inhibits BCRP efflux transport, which may raise berotralstat absorption and exposure.
處置方式
Monitor for berotralstat adverse effects such as gastrointestinal upset, and consider an ECG if risk factors for QT prolongation are present. Reduce the berotralstat dose if it is poorly tolerated.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Eltrombopag 的其他交互作用
Berotralstat 的其他交互作用
常見問題
Can I take Berotralstat with Eltrombopag?
MediHelp rates the interaction as moderate. Berotralstat and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat is a BCRP substrate, and eltrombopag inhibits BCRP. Berotralstat exposure may increase, with more gastrointestinal and QT-related adverse effects.
How serious is the interaction between Berotralstat and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for berotralstat adverse effects such as gastrointestinal upset, and consider an ECG if risk factors for QT prolongation are present. Reduce the berotralstat dose if it is poorly tolerated.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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