藥物交互作用
Amoxapine + Fluticasone-vilanterol
嚴重程度: 嚴重
Amoxapine and Fluticasone-vilanterol: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Tricyclic antidepressants can potentiate the cardiovascular effects of vilanterol, causing tachycardia, blood pressure changes and arrhythmias. Both drug classes can also prolong the QT interval.
用白話說明這項交互作用的意義
Amoxapine and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Tricyclic inhibition of norepinephrine reuptake with additive QT prolongation.
處置方式
Avoid if possible; otherwise monitor heart rate, blood pressure and ECG, and correct electrolytes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluticasone-vilanterol 的其他交互作用
常見問題
Can I take Amoxapine with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Amoxapine and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of vilanterol, causing tachycardia, blood pressure changes and arrhythmias. Both drug classes can also prolong the QT interval.
How serious is the interaction between Amoxapine and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor heart rate, blood pressure and ECG, and correct electrolytes.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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