藥物交互作用
Amitriptyline + Fluticasone-vilanterol
嚴重程度: 嚴重
Amitriptyline and Fluticasone-vilanterol: major interaction.
最後更新
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摘要
Amitriptyline can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmia and blood pressure changes, and it also prolongs the QT interval. The product label advises extreme caution with tricyclic antidepressants.
用白話說明這項交互作用的意義
Amitriptyline and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
為什麼會發生
Tricyclic noradrenaline reuptake inhibition and QT prolongation add to beta-2 agonist cardiac stimulation.
處置方式
Monitor heart rate, blood pressure and ECG, especially at the start of treatment and in patients with cardiac disease. Correct electrolytes and consider alternative therapy if arrhythmia emerges.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluticasone-vilanterol 的其他交互作用
Amitriptyline 的其他交互作用
常見問題
Can I take Amitriptyline with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Amitriptyline and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmia and blood pressure changes, and it also prolongs the QT interval. The product label advises extreme caution with tricyclic antidepressants.
How serious is the interaction between Amitriptyline and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially at the start of treatment and in patients with cardiac disease. Correct electrolytes and consider alternative therapy if arrhythmia emerges.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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