藥物交互作用
Amisulpride + Fluticasone-vilanterol
嚴重程度: 嚴重
Amisulpride and Fluticasone-vilanterol: major interaction.
最後更新
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摘要
Amisulpride prolongs the QTc interval dose-dependently, and vilanterol may add cardiac stimulation and potassium lowering. The combination may increase the risk of torsades de pointes.
用白話說明這項交互作用的意義
Amisulpride and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
為什麼會發生
Additive QTc prolongation with beta-2 agonist-related sympathetic stimulation and hypokalemia.
處置方式
Check a baseline ECG and correct potassium and magnesium before use. Repeat the ECG after starting and choose alternatives if QTc is markedly prolonged.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluticasone-vilanterol 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amisulpride with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Amisulpride and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride prolongs the QTc interval dose-dependently, and vilanterol may add cardiac stimulation and potassium lowering. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium before use. Repeat the ECG after starting and choose alternatives if QTc is markedly prolonged.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amitriptyline. The full list is on the Fluticasone-vilanterol page.
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