藥物交互作用
Amphotericin b liposomal + Benazepril
嚴重程度: 中度
Amphotericin b liposomal and Benazepril: moderate interaction.
最後更新
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摘要
Amphotericin B can cause infusion-related hypotension and renal toxicity, which may be amplified by an ACE inhibitor. Volume depletion and reduced renal function increase the likelihood of problems.
用白話說明這項交互作用的意義
Amphotericin b liposomal and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Benazepril belongs to Cardiovascular.
為什麼會發生
Additive hypotensive effect, with amphotericin nephrotoxicity and ACE inhibitor loss of efferent arteriolar tone compounding renal risk.
處置方式
Monitor blood pressure, serum creatinine and potassium during amphotericin therapy and temporarily hold benazepril if hypotension or renal decline develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Benazepril 的其他交互作用
Amphotericin b liposomal 的其他交互作用
常見問題
Can I take Amphotericin b liposomal with Benazepril?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause infusion-related hypotension and renal toxicity, which may be amplified by an ACE inhibitor. Volume depletion and reduced renal function increase the likelihood of problems.
How serious is the interaction between Amphotericin b liposomal and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium during amphotericin therapy and temporarily hold benazepril if hypotension or renal decline develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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