藥物交互作用
Amphotericin b liposomal + Captopril-hydrochlorothiazide
嚴重程度: 中度
Amphotericin b liposomal and Captopril-hydrochlorothiazide: moderate interaction.
最後更新
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摘要
Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
用白話說明這項交互作用的意義
Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Captopril-hydrochlorothiazide belongs to Cardiovascular.
為什麼會發生
Additive renal potassium and magnesium wasting, with additive effects on renal hemodynamics and volume status.
處置方式
Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Captopril-hydrochlorothiazide 的其他交互作用
Amphotericin b liposomal 的其他交互作用
常見問題
Can I take Amphotericin b liposomal with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
How serious is the interaction between Amphotericin b liposomal and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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