藥物交互作用
Amphotericin b liposomal + Melphalan
嚴重程度: 中度
Amphotericin b liposomal and Melphalan: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Amphotericin B can cause nephrotoxicity and infusion reactions, and melphalan clearance depends partly on renal function, so toxicity may be heightened with combined use. The liposomal form is less nephrotoxic but the concern is not eliminated.
用白話說明這項交互作用的意義
Amphotericin b liposomal and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Melphalan belongs to Oncology.
為什麼會發生
Possible additive renal toxicity; the mechanism of any wider interaction is not well established.
處置方式
Monitor serum creatinine, electrolytes and blood counts, and watch for hypotension or bronchospasm during infusions. Adjust melphalan dose if renal function declines.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Melphalan 的其他交互作用
- Adenovirus types 4 and 7 live + Melphalan 禁忌併用
- Bcg vaccine live + Melphalan 禁忌併用
- Influenza virus vaccine quadrivalent intranasal + Melphalan 禁忌併用
- Measles mumps and rubella vaccine live + Melphalan 禁忌併用
- Measles mumps and rubella vaccine + Melphalan 禁忌併用
- Measles mumps rubella and varicella vaccine live + Melphalan 禁忌併用
Amphotericin b liposomal 的其他交互作用
常見問題
Can I take Amphotericin b liposomal with Melphalan?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause nephrotoxicity and infusion reactions, and melphalan clearance depends partly on renal function, so toxicity may be heightened with combined use. The liposomal form is less nephrotoxic but the concern is not eliminated.
How serious is the interaction between Amphotericin b liposomal and Melphalan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and blood counts, and watch for hypotension or bronchospasm during infusions. Adjust melphalan dose if renal function declines.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
