藥物交互作用
Ampicillin-sulbactam + Doxycycline
嚴重程度: 中度
Ampicillin-sulbactam and Doxycycline: moderate interaction.
最後更新
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摘要
Bacteriostatic tetracyclines may blunt the bactericidal activity of beta-lactams, which depend on actively growing bacteria. Clinical evidence is mostly from older studies in serious infections such as meningitis.
用白話說明這項交互作用的意義
Ampicillin-sulbactam and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin-sulbactam belongs to Anti Bacterial; Doxycycline belongs to Anti Bacterial.
為什麼會發生
Tetracycline-induced inhibition of bacterial protein synthesis and growth reduces beta-lactam killing, which requires cell wall synthesis.
處置方式
Avoid the combination in severe infections such as meningitis or endocarditis where bactericidal activity is essential. Otherwise monitor clinical response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ampicillin-sulbactam 的其他交互作用
Doxycycline 的其他交互作用
常見問題
Can I take Ampicillin-sulbactam with Doxycycline?
MediHelp rates the interaction as moderate. Ampicillin-sulbactam and Doxycycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the bactericidal activity of beta-lactams, which depend on actively growing bacteria. Clinical evidence is mostly from older studies in serious infections such as meningitis.
How serious is the interaction between Ampicillin-sulbactam and Doxycycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in severe infections such as meningitis or endocarditis where bactericidal activity is essential. Otherwise monitor clinical response.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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