藥物交互作用
Allopurinol + Ampicillin-sulbactam
嚴重程度: 中度
Allopurinol and Ampicillin-sulbactam: moderate interaction.
最後更新
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摘要
Patients taking allopurinol and ampicillin have shown a higher rate of skin rash than with either drug alone. Rash is usually mild but can obscure or be mistaken for a serious hypersensitivity reaction.
用白話說明這項交互作用的意義
Allopurinol and Ampicillin-sulbactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Ampicillin-sulbactam belongs to Anti Bacterial.
為什麼會發生
Mechanism unknown; possibly additive hypersensitivity or an effect of hyperuricemia on rash.
處置方式
Counsel patients to report any rash promptly and stop the drugs if rash is severe or accompanied by fever, mucosal lesions or blistering; consider an alternative antibiotic if feasible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ampicillin-sulbactam 的其他交互作用
Allopurinol 的其他交互作用
常見問題
Can I take Allopurinol with Ampicillin-sulbactam?
MediHelp rates the interaction as moderate. Allopurinol and Ampicillin-sulbactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients taking allopurinol and ampicillin have shown a higher rate of skin rash than with either drug alone. Rash is usually mild but can obscure or be mistaken for a serious hypersensitivity reaction.
How serious is the interaction between Allopurinol and Ampicillin-sulbactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report any rash promptly and stop the drugs if rash is severe or accompanied by fever, mucosal lesions or blistering; consider an alternative antibiotic if feasible.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin-sulbactam page.
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