藥物交互作用
Apalutamide + Fluvastatin
嚴重程度: 中度
Apalutamide and Fluvastatin: moderate interaction.
最後更新
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摘要
Apalutamide is a weak CYP2C9 inducer and induces other clearance pathways. It may lower fluvastatin exposure, which is mainly cleared by CYP2C9, and so weaken its lipid-lowering effect.
用白話說明這項交互作用的意義
Apalutamide and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Fluvastatin belongs to Cardiovascular.
為什麼會發生
Apalutamide induces CYP2C9 and weakly induces transporters, increasing fluvastatin clearance.
處置方式
Monitor the lipid profile after starting or stopping apalutamide. Increase the fluvastatin dose or switch statin if efficacy is lost.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Fluvastatin 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Fluvastatin?
MediHelp rates the interaction as moderate. Apalutamide and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a weak CYP2C9 inducer and induces other clearance pathways. It may lower fluvastatin exposure, which is mainly cleared by CYP2C9, and so weaken its lipid-lowering effect.
How serious is the interaction between Apalutamide and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile after starting or stopping apalutamide. Increase the fluvastatin dose or switch statin if efficacy is lost.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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