藥物交互作用
Fluvastatin + Letermovir
嚴重程度: 嚴重
Fluvastatin and Letermovir: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.
用白話說明這項交互作用的意義
Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvastatin belongs to Cardiovascular; Letermovir belongs to Anti Virals.
為什麼會發生
Letermovir inhibits OATP1B1/3 hepatic uptake and possibly BCRP, increasing fluvastatin exposure.
處置方式
Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluvastatin 的其他交互作用
Letermovir 的其他交互作用
常見問題
Can I take Fluvastatin with Letermovir?
MediHelp rates the interaction as major. Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.
How serious is the interaction between Fluvastatin and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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