藥物交互作用
Apalutamide + Ticagrelor
嚴重程度: 嚴重
Apalutamide and Ticagrelor: major interaction.
最後更新
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摘要
Apalutamide is a strong CYP3A4 inducer and substantially lowers ticagrelor and its active metabolite exposure. This could reduce platelet inhibition and risk stent thrombosis or other ischemic events.
用白話說明這項交互作用的意義
Apalutamide and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Ticagrelor belongs to Cardiovascular.
為什麼會發生
Induction of CYP3A4 (and P-gp) increases ticagrelor clearance.
處置方式
Avoid the combination and use an alternative antiplatelet or antiandrogen. If unavoidable, monitor for loss of antiplatelet efficacy.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ticagrelor 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Ticagrelor?
MediHelp rates the interaction as major. Apalutamide and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and substantially lowers ticagrelor and its active metabolite exposure. This could reduce platelet inhibition and risk stent thrombosis or other ischemic events.
How serious is the interaction between Apalutamide and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiplatelet or antiandrogen. If unavoidable, monitor for loss of antiplatelet efficacy.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
