藥物交互作用
Aprepitant + Atogepant
嚴重程度: 中度
Aprepitant and Atogepant: moderate interaction.
最後更新
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摘要
Atogepant is a CYP3A4 substrate. Aprepitant inhibits CYP3A4 when given as a short course, so atogepant exposure is more likely to increase than decrease, and the legacy direction is doubtful. Higher atogepant levels may increase adverse effects such as nausea, constipation and fatigue.
用白話說明這項交互作用的意義
Aprepitant and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Atogepant belongs to Central Nervous System.
為什麼會發生
Aprepitant inhibits CYP3A4, reducing atogepant metabolism, although aprepitant can also induce CYP3A4 with longer exposure.
處置方式
Monitor for atogepant adverse effects during aprepitant courses. Consider dose limitation of atogepant in line with labeling for CYP3A4 inhibitors.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Aprepitant 的其他交互作用
Atogepant 的其他交互作用
常見問題
Can I take Aprepitant with Atogepant?
MediHelp rates the interaction as moderate. Aprepitant and Atogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atogepant is a CYP3A4 substrate. Aprepitant inhibits CYP3A4 when given as a short course, so atogepant exposure is more likely to increase than decrease, and the legacy direction is doubtful. Higher atogepant levels may increase adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Aprepitant and Atogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for atogepant adverse effects during aprepitant courses. Consider dose limitation of atogepant in line with labeling for CYP3A4 inhibitors.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
