藥物交互作用
Atogepant + Chloramphenicol
嚴重程度: 中度
Atogepant and Chloramphenicol: moderate interaction.
最後更新
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摘要
Chloramphenicol may inhibit CYP3A4 and increase atogepant exposure, raising the risk of adverse effects such as constipation, nausea and fatigue. Labeling recommends a lower atogepant dose with strong CYP3A4 inhibitors.
用白話說明這項交互作用的意義
Atogepant and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Chloramphenicol belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of atogepant.
處置方式
Limit atogepant to the reduced dose recommended for strong CYP3A4 inhibitors during chloramphenicol therapy. Monitor for adverse effects.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Chloramphenicol 的其他交互作用
Atogepant 的其他交互作用
常見問題
Can I take Atogepant with Chloramphenicol?
MediHelp rates the interaction as moderate. Atogepant and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and increase atogepant exposure, raising the risk of adverse effects such as constipation, nausea and fatigue. Labeling recommends a lower atogepant dose with strong CYP3A4 inhibitors.
How serious is the interaction between Atogepant and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to the reduced dose recommended for strong CYP3A4 inhibitors during chloramphenicol therapy. Monitor for adverse effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
